The Role of NGF Receptor Inhibition in Cartilage to Further Our Understanding of Osteoarthritis

By Mia Jones

EMS300 Student Conference 2026

Slide 1: The Role of NGF Receptor Inhibition in Cartilage to Further Our Understanding of Osteoarthritis. A full description follows.

Summary

The presentation explores the role of Nerve Growth Factor (NGF) receptor inhibition in understanding osteoarthritis (OA), a prevalent condition affecting over 595 million people globally. It discusses NGF's dual role in pain transmission and cartilage integrity, highlighting its upregulation in OA patients. The research utilises zebrafish models to investigate the effects of various NGF inhibitors on cartilage development. Key findings suggest that NGF signalling may influence cartilage architecture beyond pain mechanisms. Future directions for research are proposed, alongside acknowledgements of contributors and supporting personnel.