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Student conference

Identifying the Key Roles of Lamins Using Vertebrate Cells Acutely Depleted of Lamin B1 and B2

By Alecia McKinley

EMS300 Student Conference 2026

Slide 1: Identifying the key roles of Lamins using vertebrate cells acutely depleted of Lamin B1 and B2. A full description follows.

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Summary

The presentation investigates the roles of B-type lamins in vertebrate cells, particularly focusing on their depletion effects on chromatin organisation and cell growth. Lamins, crucial structural proteins of the nuclear lamina, are linked to various laminopathies, including Hutchison-Gilford Progeria Syndrome. The research aims to deplete B-type lamins from DT40 cells, revealing that their absence leads to reduced long-term growth and dispersal of heterochromatin. The findings underscore the importance of B-type lamins during embryogenesis and organogenesis.

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