Role of Obesity Gene PLXNA4 in Neurodevelopment and Anxiety

By Madeleine Cowie

EMS300 Student Conference 2026

Slide 1: Role of Obesity Gene. A full description follows.

Summary

The presentation explores the role of the obesity gene PLXNA4 in neurodevelopment and its potential link to anxiety. It builds on genetic studies indicating PLXNA4's involvement in the hypothalamic leptin-melanocortin pathway, crucial for satiety regulation. The research utilises zebrafish models to assess neurodevelopmental changes and anxiety behaviours associated with PLXNA4 loss. Preliminary findings suggest disrupted neuron development and a trend towards increased anxiety in mutants, although further research with larger cohorts is necessary to confirm these results. The study aims to elucidate shared biological pathways between obesity and anxiety.