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Student conference

The Non-Invasive Quantification of Liver Necrosis

By Charlotte Potter

EMS300 Student Conference 2026

Slide 1: 1. A full description follows.

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Summary

Research on a non-invasive method to quantify liver necrosis due to acetaminophen (APAP) injury focuses on serum miR-122 as a predictive biomarker. The study establishes a significant correlation between miR-122 levels and necrosis, with a high statistical significance (p-value = 0.0000000000000016) and explaining 77.5% of variance in necrosis prediction. However, the findings indicate a weak correlation at earlier time points and highlight limitations such as outliers and technical errors. The research aims to enhance clinical prognostication and reduce animal testing.

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