Investigating the Role of SAF-A and Transcription in Nuclear Organisation

By Tamanna Bostani

EMS300 Student Conference 2026

Slide 1: Investigating the Role of SAF-A and Transcription in Nuclear Organisation. A full description follows.

Summary

The presentation investigates the role of SAF-A and transcription in nuclear organisation, focusing on how transcription inhibition and SAF-A depletion may alter this organisation in RPE1-SD cells. Key findings indicate that transcription inhibition leads to condition-dependent changes in nuclear heterogeneity, with α-amanitin showing significant effects. The study highlights the potential link between chromatin-associated proteins and cancer cell adaptation. Future directions include assessing the response of SAF-A-depleted cells to anti-cancer drugs and employing high-throughput imaging techniques to analyse nuclear morphology.